tag:blogger.com,1999:blog-51846086760422068.post6168074042281071335..comments2024-03-28T08:37:08.964-07:00Comments on Open Flask: Column Chromatography....seems silly now.BaranLabhttp://www.blogger.com/profile/01806245988209508968noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-51846086760422068.post-2036633680783423972019-02-17T23:38:41.158-08:002019-02-17T23:38:41.158-08:00Nice Post!
Liquid Column ChromatographyNice Post!<br /><a href="https://livescience.info/what-do-you-know-about-liquid-mobile-phase-in-a-column-method-and-partition-methods-of-chromatography/" rel="nofollow">Liquid Column Chromatography</a><br />junaid.mustafa@GMAIL.COMhttps://www.blogger.com/profile/07808112182348274808noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-10294869028575629452017-10-27T03:12:30.138-07:002017-10-27T03:12:30.138-07:00Softhof is providing cheapest web hosting we also ...Softhof is providing cheapest web hosting we also offering dedicated website hosting for the first time in Lahore Pakistan. We provide to our customers 24/7 services to our honorable customers with 99.9% up time guarantee. Softhof offers best web hosting services in Pakistan. You may utilize free Domain & Hosting for experiments or to run professional websites and free domain hosting can also refer to website hosts services that provide a free domain name included with their free webhosting plan. <br /><a href="http://softhof.com/" rel="nofollow"> Web Hosting in Pakistan</a>Anonymoushttps://www.blogger.com/profile/05576891667433324911noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-8514084613535838102014-12-13T04:40:36.803-08:002014-12-13T04:40:36.803-08:00useful information on topics that plenty are inter...useful information on topics that plenty are interested on for this wonderful post.<br /><a href="http://www.bigcitymovingco.com/full-service-movers/" rel="nofollow">bigcitymoving.com</a><br />Anonymoushttps://www.blogger.com/profile/10161378138086950442noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-87249622755113946372014-10-16T03:43:04.157-07:002014-10-16T03:43:04.157-07:00Your blog is awesome and really helpful for reader...Your blog is awesome and really helpful for readers. Many <a href="http://www.custompeptideservices.com/" rel="nofollow">Custom peptide</a> provide online peptide services.Anonymoushttps://www.blogger.com/profile/13252636315596716579noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-91788186258689259092014-01-08T03:36:03.381-08:002014-01-08T03:36:03.381-08:00Column chromatography is separated into two catego...<a href="http://www.sorbeadindia.com/silica-gel-column-chromatography.html" rel="nofollow">Column chromatography</a> is separated into two categories, depending on how the solvent flows down the column. If the solvent is allowed to flow down the column by gravity, or percolation, it is called gravity column chromatography. If the solvent is forced down the column by positive air pressure, it is called flash chromatography, a "state of the art" method currently used in organic chemistry research laboratories.Anonymoushttps://www.blogger.com/profile/16460175107485447757noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-39767831146243150822013-05-02T13:10:14.836-07:002013-05-02T13:10:14.836-07:00Very good summary of the technology and what it ca...Very good summary of the technology and what it can do. My company AMPAC Fine Chemicals has been doing large scale chiral separations for pharmaceuticals (>100T a year!) for about 14 years now on SMB units with 80 cm or 1 meter column diameter. Solvent recycling is about 99.98% and packing is rarely replaced if the separation conditions are done right. I encourage you to join the continuous chromatography group on linkedin or to attend the Prep conference (this year in Boston July 15-17). <br />If you want more details about the technology feel free to contact me at olivier.dapremont@apfc.com<br /><br /><br />OlivierDhttps://www.blogger.com/profile/00521192816526319901noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-64730160416700501122013-04-07T05:51:41.937-07:002013-04-07T05:51:41.937-07:00I remember back when I was in undergraduate (aroun...I remember back when I was in undergraduate (around 2007), we had the visit of an industrial (from Novartis I guess, can't be sure) who adertised for this technique, with the same king of picture, turtle and rabbit on a moving bed.<br />I'm still very enthusiastic about the concept, it's just a shame it still can't be applied on routine in research... it would save so much time !PGMChemhttps://www.blogger.com/profile/08734755588204060141noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-42282490748429503082013-03-28T18:47:16.992-07:002013-03-28T18:47:16.992-07:00It gets even more interesting when one of your sta...It gets even more interesting when one of your stationary phases is 'reactive' - for example, you can perform a kinetic resolution by having one column contain a racemase enzyme, then drive the reaction by continuously removing the desired enantiomer, while the unwanted one is recycled.Aexhttps://www.blogger.com/profile/13803108105616907076noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-11855409730831563192013-03-28T03:20:25.851-07:002013-03-28T03:20:25.851-07:00I was at a conference this week and this technique...I was at a conference this week and this technique has been developed and now can purify multi-component mixtures continuously. Take a look at Multicolumn Countercurrent Solvent Gradient Purification from Prof. Massimo Morbidelli at ETH ZurichS Robinsonhttps://www.blogger.com/profile/06630169750200689866noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-88035744652801631822013-03-21T10:17:49.027-07:002013-03-21T10:17:49.027-07:00I came here to read these kinds of interesting art...I came here to read these kinds of interesting articles and to be highly motivated everyday.<br />Thank you every time and plz continue posting lol. - from half a world away, S.Korea.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-57681826105913592772013-03-19T09:57:25.829-07:002013-03-19T09:57:25.829-07:00You're right there are definitely some real te...You're right there are definitely some real technical challenges there with monitoring and regenerating stationary phase. But if you're just separating enantiomers your mixture is likely binary (by definition) and pure and the beauty is certainly that you don't have to collect fractions.Stevehttps://www.blogger.com/profile/07992347690568645057noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-78745988529283010712013-03-19T09:22:54.981-07:002013-03-19T09:22:54.981-07:00You do not actually need to have a set of identica...You do not actually need to have a set of identical columns for doing simulated moving bed separation. The same principle can be easily applied with just one (expensive chiral) column, autoinjector and automated fraction collector: You would run series of identical separations with isocratic elution - the only difference from normal setup is that the runs are performed without waiting for the current run to complete before injecting new mix. The injection intervals are spaced just enough to ensure a complete elution of the slower enantiomer before the faster enantiomer from the next injection starts coming out. The corresponding fractions in the fraction collector are then combined<br /><br />On this one-column example we can easily see the limitations and potential pitfalls of simulated bed - the separated mix has to be binary (and otherwise pure so that gunk does not build up on the column) and the column performance has to be monitored and the system occasionally adjusted as the optimum injection interval time can gradually drift during a long continuous run...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-27258186798997445192013-03-19T05:21:06.107-07:002013-03-19T05:21:06.107-07:00Very clever indeed!Very clever indeed!Kromablographyhttps://www.blogger.com/profile/08986235097678792994noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-24170772972339097022013-03-18T21:31:59.860-07:002013-03-18T21:31:59.860-07:00Nice post, well explained. Nice post, well explained. Chemjobberhttps://www.blogger.com/profile/15932113680515602275noreply@blogger.com