tag:blogger.com,1999:blog-51846086760422068.post2024860860486861698..comments2024-03-28T08:37:08.964-07:00Comments on Open Flask: A Taxol synthesis is simpleBaranLabhttp://www.blogger.com/profile/01806245988209508968noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-51846086760422068.post-33354334454897620252013-04-07T07:17:09.909-07:002013-04-07T07:17:09.909-07:00Was this reviewer an actual chemist? Probably not ...Was this reviewer an actual chemist? Probably not an organic one, for sure...<br /><br />That is the trouble when you try to explain your work to people unfamiliar with the field. You need to keep it simple enough so they don't get lost whilst keeping it looking difficult. A hard balance to find.<br /><br />Sorry for your fellowship.PGMChemhttps://www.blogger.com/profile/08734755588204060141noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-26149666819374174132013-04-03T16:24:53.500-07:002013-04-03T16:24:53.500-07:00a colleague once lost it, on a big company medchem...a colleague once lost it, on a big company medchem project meeting with the management and biologists and crystallographers and computer modeling guys in audience - few of them visibly aspiring for promotion - after "helpful" comments how great it would be to make dozen additional analogs to test the binding mode hypothesis - with various rings swapped and functional groups moved around here and there. He bellowed: "You guys really think we make this from LEGO?" Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-85157430106920294572013-04-03T14:42:11.132-07:002013-04-03T14:42:11.132-07:00Unfortunately, there is a lot of harsh criticism, ...Unfortunately, there is a lot of harsh criticism, even hostility, towards synthesis - and I share your view that some of it may simple be due to ignorance. We need to explain better why this is hard and where are the challenges. Thanks for sharing this.PMPhttps://www.blogger.com/profile/16625022840174919532noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-87315360558007901902013-03-31T09:21:15.681-07:002013-03-31T09:21:15.681-07:00Face it, you're TOO good at total synthesis. Y...Face it, you're TOO good at total synthesis. You make the flat-out impossible seem trivial, but is that a blessing, or a curse?Andrehttps://www.blogger.com/profile/12140011313455957356noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-2616615258206330692013-03-29T21:52:22.668-07:002013-03-29T21:52:22.668-07:00Sorry, dude, that sucks. I think you've drawn ...Sorry, dude, that sucks. I think you've drawn the right lesson from it. Chemjobberhttps://www.blogger.com/profile/15932113680515602275noreply@blogger.com