tag:blogger.com,1999:blog-51846086760422068.post5591467130309348166..comments2024-03-22T05:29:38.457-07:00Comments on Open Flask: ΨBaranLabhttp://www.blogger.com/profile/01806245988209508968noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-51846086760422068.post-68687097243887240012020-09-09T10:01:29.238-07:002020-09-09T10:01:29.238-07:00Have you tried this reaction with other nucleophil...Have you tried this reaction with other nucleophiles, particularly phenols? Or it works only with alcohols?Aloisiohttps://www.blogger.com/profile/13770746894194943193noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-67248681997874170172018-08-16T10:58:16.301-07:002018-08-16T10:58:16.301-07:00We took it down because it did not reflect proper ...We took it down because it did not reflect proper laboratory safety protocols. The high level summary is that the reaction is extremely easy (and safe) to run :) BaranLabhttps://www.blogger.com/profile/01806245988209508968noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-45719381780775317922018-08-15T14:13:58.346-07:002018-08-15T14:13:58.346-07:00Hey what happened to y'alls youtube video??Hey what happened to y'alls youtube video?? Anonymoushttps://www.blogger.com/profile/03501000997858234438noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-77581157943316644932018-08-06T19:07:12.971-07:002018-08-06T19:07:12.971-07:00Hi Milkshake,
Thank you for the comment, always a...Hi Milkshake,<br /><br />Thank you for the comment, always appreciated! While we understand the specific concerns being raised, we have no reason to believe that there are any particular hazards when working with our reagents. We suggest taking care similar to when using P(O)Cl3 and compounds of the like. Anonymoushttps://www.blogger.com/profile/00515932111306451150noreply@blogger.comtag:blogger.com,1999:blog-51846086760422068.post-17308881865002757232018-08-04T13:34:12.097-07:002018-08-04T13:34:12.097-07:00The development of Ψ reagents is very impressive. ...The development of Ψ reagents is very impressive. But if it is going to be commercial, and widely used, it would be worth to do a simple test of acetylcholinesterase activity on these reagents, especially their decomposition products in the presence of DBU (or similar strong guanidine bases like TMG or TBD). I worry someone might mess up the procedure (for example by adding reagents in the wrong order, and with some delay) and inadvertently prepare Novichok-like neurotoxic byproduct. One has to be on lookout when working with P(V)organophosphate analogs containing a good leaving group such as a thioester. milkshakehttps://www.blogger.com/profile/08188961610554710616noreply@blogger.com