Monday, January 14, 2019

Technique primer: Test tube columns

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As many of you remember, a little over a year ago Phil did a AMA on reddit . On that AMA, a bunch of people requested that we do a post on h...
10 comments:
Sunday, January 13, 2019

11-Step Total Synthesis of Teleocidins B-1–B-4

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Our paper describing the total synthesis of Teleocidins B-1–B-4 is now published in JACS ! I started working on this project in November 20...
8 comments:
Thursday, January 3, 2019

Decarboxylative carboxylation: radiolabeling carboxylic acids the easy way

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Our latest paper, which arose from a collaboration with the radiochemistry team at BMS, describes a new approach to carbon-14 radiolabeling...
1 comment:
Friday, December 21, 2018

Simply Strained: Total Synthesis of Herqulines

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Our recent syntheses of herqulines B and C have been published today in JACS . While the paper describes the direct nature of our final ...
11 comments:
Thursday, August 2, 2018

Ψ

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August marks the start of the academic year here at TSRI, and with every new semester I become a bit retrospective about my own first year ...
5 comments:
Monday, July 30, 2018

What if Diels, Alder, and Suzuki had a Love Child?

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Today our most recent work combining decarboxylative cross–couplings with cycloadditions to generate complex C( sp 3 ) rich compounds was p...
23 comments:
Tuesday, June 26, 2018

Radicals can DELiver for DEL

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You may have noticed that our work on sp 3 -sp 3 C-C coupling for DNA encoded library (DEL) synthesis was deposited on Chemrxiv about  two...